Nattokinase Research Studies
Nattokinase is an enzyme extracted and purified from a Japanese food called Natto. Natto is a traditional food made from soybeans fermented with the bacterium, Bacillus subtilis, and has been consumed for more than 1000 years, especially in the eastern Kanto Region of Japan.[SUP]1,2,3,4[/SUP]
Nattokinase has been the subject of 17 studies, including two small human trials. In 1990, Dr. Sumi's research team published a series of studies demonstrating the fibrinolytic effects of Nattokinase.[SUP]9[/SUP] Here are some of them:
Dissolves blood clots
Researchers from JCR Pharmaceuticals, Oklahoma State University, and Miyazaki Medical College, tested Nattokinase on 12 healthy Japanese volunteers (6 men and 6 women, between the ages of 21 and 55). The researchers gave the volunteers 7 ounces of natto (the food) before breakfast, and then tracked fibrinolytic activity through a series of blood plasma tests.
In one test, a blood sample was taken and a thrombus (clot) was artificially induced. The amount of time needed to dissolve the clot was cut in half within 2 hours of treatment, compared to the control group. Additionally, the volunteers retained an enhanced ability to dissolve blood clots for up to 8 hours.[SUP]9 [/SUP]
Dr. Sumi's team also induced blood clots in a major leg vein in male dogs that had been given either four capsules of Nattokinase (250 mg per capsule) or four placebo capsules. Angiograms (x-rays of blood vessels) showed that the blood clots in the dogs that received Nattokinase had completely dissolved within 5 hours of treatment, and that normal blood circulation had been restored. Blood clots in the dogs who received the placebo showed no sign of dissolving 18 hours after the treatment.[SUP]9 [/SUP]
Researchers from Biotechnology Research Laboratories and JCR Pharmaceuticals Co. of Kobe, Japan, tested Nattokinase's ability to dissolve a blood clot in the carotid arteries of rats. Animals treated with Nattokinase regained 62 percent of blood flow, whereas those treated with plasmin regained just 15.8 percent of blood flow.[SUP]1,9[/SUP]
In another laboratory study, endothelial damage was induced in the femoral arteries of rats that had been given Nattokinase. In normal circumstances, a thickening of the artery walls and blood clotting would occur, but they were both suppressed because of Nattokinase's fibrinolytic activity.[SUP]10 [/SUP]