It's like various drugs. I've taken Vicodin, tramadol, Anacin, Excedrin, Aleve, Percocet, percodan, oxycodone and ibuprofen.
Percocet was nothing.
Percodan resulted in rubber legs
Vicodin and Tramadol were good enough for some relief.
Anacin, Excedrin were good for headaches.
Aleve (and generic) are so-so
Ibuprofen fair for minor aches.
Oxycodone 5 hours sleep.
I've had a PKG of them, I'm guessing they were mild as I felt no change. I'm going to try making brownies with some weed and see if that helps.
My first time with Vicodin was after a tooth was pulled. Dentist gave me 10 for pain. It took three 5/500 to give a buzz. It takes two 10/375 to do the same.
I know some who can't take half of what I could and they outweigh me by a margin, or are rail thin, same result.