The best solution would be if you can figure out what causes it. For example:
I love hiking and always carried a cane in my right hand. Then I developed sciatica. After much trial and error, I discovered that changing the cane between both hands (instead of having it ONLY in my right hand) got rid of my sciatica pain.
Too much hiking in my mid 80's caused damage to my left hip. An orthopedic surgeon gave me a shot into my left hip, the pain went away AND BASTA, my back pain was also gone. Indeed, the sciatica nerve connects both areas. Solving the problem in one area also solved the problem in the other area.
Sitting too long also caused me sciatica pain. After much trial and error, I discovered that sitting on a four-inch foam pillow got rid of this type of sciatica pain.
OTC Voltaren arthritis cream (both Costco and Sam's Club carry it) worked wonders for me to eliminate sciatica pain for a week or so. But check with your physician first.
PS, I think Prednisone is by prescription only because it could damage the liver ???
PPS, in extreme cases, a vertebra surgery will bring relief.