Yes. It could be multiple reasons from just aging/downsizing to environmental changes that can cause drinking water pollution and air pollution. Or noise
issues, HOA disagreements, bad neighbors, bad local government issues, nearby chicken plant or nuclear plant, poor school scores, home depreciation
instead of keeping pace with the market, future expansion plans like a highway/Condo/Hotel planning to be developed next to you, etc.
Your realtor should be able to suss it out for you if they are trustworthy...remember, they DO want to make a quick sale so some will not tell what they don't
have to tell.