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The world's oldest conjoined twins Lori and George Schappell have died at the age of 62.
Lori and her transgender twin George passed away on Sunday at a hospital in Pennsylvania due to undisclosed causes, per their online obituaries.
The siblings, who had partially-fused skulls and shared 30 per cent of their brains, defied doctors who said they wouldn't live past the age of 30.
The twins had previously made headlines after George, formerly Dori, came out as transgender.
Lori was able-bodied but George, who had spina bifida, was confined to a wheelchair which his twin pushed around.
He had enjoyed a successful career as a country singer but Lori pursued her interests elsewhere as a trophy-winning ten-pin bowler.
She also worked at a hospital laundry for several years during the '90s, arranging her schedule around George's gigs, which took them around the world to countries including Germany and Japan, according to the Guinness World Records.
The siblings became the first same-sex conjoined twins to identify as different genders after George, whose original name was Dori, came out as a transgender man in 2007.
It was at this point that he changed his name from Reba - a moniker he took up to honor his idol Reba McEntire because he disliked their rhyming names - to George.
The twins lived independently in a two-bedroom apartment in Pennsylvania where they took turns practicing their separate hobbies.
They alternated whose room they slept in and also showered separately by using the shower curtain as a barrier as one stood outside the bath.
The pair appeared on numerous shows including Jerry Springer, The Maury Povich Show and The Howard Stern Radio Show.
World's oldest conjoined twins Lori and George Schappell dead at 62
R.I.P... to 2 people who never let life get in their way
Lori and her transgender twin George passed away on Sunday at a hospital in Pennsylvania due to undisclosed causes, per their online obituaries.
The siblings, who had partially-fused skulls and shared 30 per cent of their brains, defied doctors who said they wouldn't live past the age of 30.
The twins had previously made headlines after George, formerly Dori, came out as transgender.

Lori was able-bodied but George, who had spina bifida, was confined to a wheelchair which his twin pushed around.
He had enjoyed a successful career as a country singer but Lori pursued her interests elsewhere as a trophy-winning ten-pin bowler.
She also worked at a hospital laundry for several years during the '90s, arranging her schedule around George's gigs, which took them around the world to countries including Germany and Japan, according to the Guinness World Records.
The siblings became the first same-sex conjoined twins to identify as different genders after George, whose original name was Dori, came out as a transgender man in 2007.
It was at this point that he changed his name from Reba - a moniker he took up to honor his idol Reba McEntire because he disliked their rhyming names - to George.
The twins lived independently in a two-bedroom apartment in Pennsylvania where they took turns practicing their separate hobbies.
They alternated whose room they slept in and also showered separately by using the shower curtain as a barrier as one stood outside the bath.
The pair appeared on numerous shows including Jerry Springer, The Maury Povich Show and The Howard Stern Radio Show.

World's oldest conjoined twins Lori and George Schappell dead at 62
R.I.P... to 2 people who never let life get in their way