Missouri has been gradually re-opening since the beginning of the year, and so far the numbers are staying fairly low. Vaccinations have been steadily increasing in the past few weeks, and there is enough vaccine to allow everyone over the age of 16 to schedule a shot, starting April 1st. There are still some restrictions on the numbers of people allowed to gather in bars, restaurants, etc., but if present trends continue, that should be removed by early Summer. Most stores are still asking people to wear masks, and not gang up at the checkouts/cash register, and most people are behaving fairly well. The remaining "hot spots" seem to be in the major cities...KC, St. Louis, etc.
It appears that these vaccines are working well, with minimal side effects. The trick now will be convincing millions of sceptics that getting vaccinated is the best way, perhaps the Only way, to allow the nation to return to normal.