If reality doesn't exist, it wouldn't change anything about my life. I wouldn't join a cult or subscribe to a Flat Earth Society publication. Unfortunately, if reality doesn't exist, I doubt that I would exist. Not that I hadn't contemplated something similar to the Matrix, even before the movie came out, but I passed on the idea rather quickly.
One thing I've thought about at some length is whether something came from nothing. This is also a dead argument, but if something did come from nothing, could it be possible that everything around us is just a different manifestation of nothing. After all, protons seem to be 99+% nothing, and sub atomic particles appear and disappear as if half their life is a nothing state.
But again, none of this has any practical application on how I go about my life.