Tried a new medication for depression

Mr. Ed

Mr. Ed

Be what you is not what you what you ain’t
Location
Central NY
Auvelity is a new medication for MDD. Didn’t work, had a bunch undesirable side affects. Weaning myself off per doctors advice. Will increase dosage of Effexor. I have treatment resistant depression meaning I have run the gambit as far as medication goes. I have had TMS 2 times, the 2nd time didn’t work.
 

Mr. Ed said:
Auvelity is a new medication for MDD. Didn’t work, had a bunch undesirable side affects. Weaning myself off per doctors advice. Will increase dosage of Effexor. I have treatment resistant depression meaning I have run the gambit as far as medication goes. I have had TMS 2 times, the 2nd time didn’t work.
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Sorry to hear it didn't work out, Mr. Ed. But that's par for the course with treatments for depression - not only does it sometimes take weeks to know if it's having any effect, you find it didn't help and have to come off it.

I know there are some studies going on using Ketamine, apparently they look promising. However, there are so many variables.
 
PeppermintPatty said:
Yes!
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from pi.ai

Does Ketamine produce ego loss?

Yes, high doses of ketamine (150-200 mg, or 1.5-2.0 mg/kg) can lead to ego dissolution, a state in which one's sense of self and identity temporarily disappears. This experience can be accompanied by "life-in-review" memories, transcendental experiences, and visions, even with eyes open.
There are two common manifestations of ego loss during a ketamine experience:
  1. You may feel as though you're having a near-death experience, reliving your life through a narrative of memories, and becoming more aware of how your actions have affected others. In this state, you remain aware of who you are, but it's like watching yourself from the outside.
  2. You may lose your complete sense of self and feel as though you've joined the collective unconscious or experienced a sacred unity with nature or the universe.
It's important to note that ego loss experiences can be profound and potentially life-changing, but they should be approached with caution and under the guidance of medical professionals, especially when using high doses of ketamine.

what is the source of that information?

The information about ketamine and ego loss comes from a combination of scientific studies, clinical research, and anecdotal reports from individuals who have experienced ego loss during ketamine use. Here are some specific sources:
  • A study titled "Ketamine for Treatment-Resistant Depression: The First Decade of Progress" published in the American Journal of Psychiatry in 2018 discussed the dissociative effects of ketamine, including ego dissolution.
  • An article by Dr. Raquel Bennett, a psychiatrist and ketamine therapy provider, described the ego dissolution experience as part of the therapeutic benefits of ketamine for mental health disorders.
  • Several anecdotal reports from individuals who have used ketamine recreationally or therapeutically also describe experiences of ego loss, which have been shared on forums like Reddit, Erowid, and Bluelight.
These sources provide valuable insights into the potential effects of ketamine on ego dissolution, as well as its therapeutic applications for mental health disorders.
 
Paco Dennis said:
from pi.ai

Does Ketamine produce ego loss?

Yes, high doses of ketamine (150-200 mg, or 1.5-2.0 mg/kg) can lead to ego dissolution, a state in which one's sense of self and identity temporarily disappears. This experience can be accompanied by "life-in-review" memories, transcendental experiences, and visions, even with eyes open.
There are two common manifestations of ego loss during a ketamine experience:
  1. You may feel as though you're having a near-death experience, reliving your life through a narrative of memories, and becoming more aware of how your actions have affected others. In this state, you remain aware of who you are, but it's like watching yourself from the outside.
  2. You may lose your complete sense of self and feel as though you've joined the collective unconscious or experienced a sacred unity with nature or the universe.
It's important to note that ego loss experiences can be profound and potentially life-changing, but they should be approached with caution and under the guidance of medical professionals, especially when using high doses of ketamine.

what is the source of that information?

The information about ketamine and ego loss comes from a combination of scientific studies, clinical research, and anecdotal reports from individuals who have experienced ego loss during ketamine use. Here are some specific sources:
  • A study titled "Ketamine for Treatment-Resistant Depression: The First Decade of Progress" published in the American Journal of Psychiatry in 2018 discussed the dissociative effects of ketamine, including ego dissolution.
  • An article by Dr. Raquel Bennett, a psychiatrist and ketamine therapy provider, described the ego dissolution experience as part of the therapeutic benefits of ketamine for mental health disorders.
  • Several anecdotal reports from individuals who have used ketamine recreationally or therapeutically also describe experiences of ego loss, which have been shared on forums like Reddit, Erowid, and Bluelight.
These sources provide valuable insights into the potential effects of ketamine on ego dissolution, as well as its therapeutic applications for mental health disorders.
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The more I learn about this stuff the more I don’t ever want to try it.
 
VaughanJB said:
The thing to remember is that they're testing it for treatment of depression. Depression itself can be a life threatening illness. Entire lives are spent battling against oneself. It may not be for everyone, but we should be considering new treatments, imo.
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I understand that it’s an experimental treatment . I also understand depression. I actually have a depressive disorder and am currently depressed. It certainly can be life threatening. Patients need to weigh the pros and cons of each treatment to see what best suites them. Not everyone can take anti depressants. For some people it makes it worse.
 
PeppermintPatty said:
I understand that it’s an experimental treatment . I also understand depression. I actually have a depressive disorder and am currently depressed. It certainly can be life threatening. Patients need to weigh the pros and cons of each treatment to see what best suites them. Not everyone can take anti depressants. For some people it makes it worse.
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I live in the hope that it's just a matter of finding what works. If I were to think about there being no treatment that works, then the world would be a much gloomier place.
 
VaughanJB said:
I live in the hope that it's just a matter of finding what works. If I were to think about there being no treatment that works, then the world would be a much gloomier place.
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At the moment I’m on medication that helps greatly. It’s not a medication I would have expected to help, but it does. The depression is still there but not as bad.

Months ago when I first read about Ketamine, I had high hopes but the more I learn about it the more I think it’s not for me. I didn’t realize that the medication is given via a needle.
 
PeppermintPatty said:
At the moment I’m on medication that helps greatly. It’s not a medication I would have expected to help, but it does. The depression is still there but not as bad.

Months ago when I first read about Ketamine, I had high hopes but the more I learn about it the more I think it’s not for me. I didn’t realize that the medication is given via a needle.
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Same with Cannabis. They put regulations in place that prevented it truly being studied as a medicine. The world is a strange strange place.
 
VaughanJB said:
Same with Cannabis. They put regulations in place that prevented it truly being studied as a medicine. The world is a strange strange place.
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I’ used cannabis successfully since 1977. I grew my own and made my own edibles. Just this last year I found myself having allergic reactions to it. I was getting sinus infections and becoming very paranoid. I finally quit 3 months ago. I’ve got mixed feelings about it. I’m proud of myself for getting off of it but wish I could find something that worked just as good. I really liked that I had complete control over how much I used. It really wasn’t a lot. Maybe 1/2 a gram at most a day. There’s a lot of good things that can be said about cannabis. It’s a very good pain reliever.
I wish I didn’t have to go off it.
It’s legal where I live but I’ve had a card since 2007.
 
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I would love to try something for depression but I am on so many medications that I hesitate to add another one. Some of my depression seems to depend on luck or situations where I have no control. Are there interesting, caring people around? Not often. Do I have faith in my fellow Americans? It is pretty shaky. Hoping for hope.
 
Maybe you're not treatment resistant. Maybe those medications are BS. Anyway, they aren't designed to *cure* depression, only to make you feel different.

Only counseling with a trained therapist has a potential for curing depression. It at least helps people cope with it, manage it, and/or live with it peacefully.
 

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