Huge breast cancer breakthrough

[hollydolly]

as Scottish scientists discover key way to prevent deadly disease​

Scientists have discovered how breast cancer spreads to other parts of the body—and it could revolutionise how the disease is treated in its earlier stages.

Scottish researchers discovered that cancer changes the metabolism—the way cells make and use energy—of specific immune cells.

They found that they release a certain sort of protein, called uracil, which can be used as a 'scaffold' by cancerous cells, allowing them to grow on other organs.

Scientists were able to block the uracil-powered scaffold from forming in mice.

This restored the ability of the creatures' immune systems to kill secondary cancer cells, and stop the cancer from spreading.

The scientists achieved this by blocking an enzyme called uridine phosphorylase-1 (UPP1), which produces uracil.

They hope that detecting uracil in the blood may help spot early signs the cancer spreading—and blocking UPP1 with drugs could stop the spread before it even starts.

Lead author of the study, Dr Cassie Clarke, said: 'This study represents a major shift in how we think about preventing the spread of cancer.

'By targeting these metabolic changes as early as possible we could stop the cancer progressing and save lives.'

Meanwhile, Dr Catherine Elliot, director of research at Cancer Research UK, said: 'Metastasis—when cancer spreads—is a major factor in breast cancer becoming harder to treat, especially if the cancer returns months or even many years later.

'This discovery gives us new hope for detecting and stopping metastasis early

The research may also help stop the spread of other cancers to other parts of the body, too added Simon Vincent, chief scientific officer at Breast Cancer Now.

'Now we need more research to see if this new insight can be turned into new drugs that stop secondary breast cancer, and potentially other secondary cancers,' he said.

The team of researchers at from the Cancer Research UK Institute and University of Glasgow are now testing the ability of drugs to prevent cancer occurring.


It comes amid an alarming prediction earlier this year that breast cancer deaths in the UK will soar by more than 40 per cent by 2050.

By the same year, globally, another study estimated there will be 3.2million new cases and 1.1million breast-related deaths per year if current trends continue.

The disease is far more prevalent in those over 50, which is the age women typically experience the menopause.

It is the most common type of cancer in the UK, taking the lives of around 11,500 Britons and 42,000 Americans each year.


Scientists discover key way to prevent deadly disease

 

[Paladin1950]

My niece had breast cancer a few years ago. Unfortunately, she had to have a double mastectomy.

 

[Sunny]

as Scottish scientists discover key way to prevent deadly disease​

Scientists have discovered how breast cancer spreads to other parts of the body—and it could revolutionise how the disease is treated in its earlier stages.

Scottish researchers discovered that cancer changes the metabolism—the way cells make and use energy—of specific immune cells.

They found that they release a certain sort of protein, called uracil, which can be used as a 'scaffold' by cancerous cells, allowing them to grow on other organs.

Scientists were able to block the uracil-powered scaffold from forming in mice.

This restored the ability of the creatures' immune systems to kill secondary cancer cells, and stop the cancer from spreading.

The scientists achieved this by blocking an enzyme called uridine phosphorylase-1 (UPP1), which produces uracil.

They hope that detecting uracil in the blood may help spot early signs the cancer spreading—and blocking UPP1 with drugs could stop the spread before it even starts.

Lead author of the study, Dr Cassie Clarke, said: 'This study represents a major shift in how we think about preventing the spread of cancer.

'By targeting these metabolic changes as early as possible we could stop the cancer progressing and save lives.'

Meanwhile, Dr Catherine Elliot, director of research at Cancer Research UK, said: 'Metastasis—when cancer spreads—is a major factor in breast cancer becoming harder to treat, especially if the cancer returns months or even many years later.

'This discovery gives us new hope for detecting and stopping metastasis early

The research may also help stop the spread of other cancers to other parts of the body, too added Simon Vincent, chief scientific officer at Breast Cancer Now.

'Now we need more research to see if this new insight can be turned into new drugs that stop secondary breast cancer, and potentially other secondary cancers,' he said.

The team of researchers at from the Cancer Research UK Institute and University of Glasgow are now testing the ability of drugs to prevent cancer occurring.


It comes amid an alarming prediction earlier this year that breast cancer deaths in the UK will soar by more than 40 per cent by 2050.

By the same year, globally, another study estimated there will be 3.2million new cases and 1.1million breast-related deaths per year if current trends continue.

The disease is far more prevalent in those over 50, which is the age women typically experience the menopause.

It is the most common type of cancer in the UK, taking the lives of around 11,500 Britons and 42,000 Americans each year.


Scientists discover key way to prevent deadly disease

Any legitimate weapon in the fight against cancer sounds good to me. This will probably be one more in the substances detectable by blood tests, mammograms, etc. that are instrumental in the formation of cancer, at a very early stage.

I once had a diagnosis of something that was nearly cancer - I call it "pre-cancer." It was stage 0, microscopic in size, detected in a regular mammogram because there were tiny "calcifications," little white spots, that showed up on the picture. Since then, I've learned that radiologists routinely look for those calcifications.

They will probably add uracil detection to their army of early cancer spotters. At that point, with calcifications, it's curable by a simple office surgical procedure. ( I don't know what they do about uracil but it's probably similar.) Good news!

 

[Kaila]

Excellent, wonderful read. !!!
Thank you for posting it, @hollydolly
!!

 

[KSav]

This is really good news! Thanks for sharing it, @hollydolly. I started getting mammograms every year at age 30 because of a family history. I have one next week. As I get older, I get more and more anxious.

 

[Leann]

as Scottish scientists discover key way to prevent deadly disease​

Scientists have discovered how breast cancer spreads to other parts of the body—and it could revolutionise how the disease is treated in its earlier stages.

Scottish researchers discovered that cancer changes the metabolism—the way cells make and use energy—of specific immune cells.

They found that they release a certain sort of protein, called uracil, which can be used as a 'scaffold' by cancerous cells, allowing them to grow on other organs.

Scientists were able to block the uracil-powered scaffold from forming in mice.

This restored the ability of the creatures' immune systems to kill secondary cancer cells, and stop the cancer from spreading.

The scientists achieved this by blocking an enzyme called uridine phosphorylase-1 (UPP1), which produces uracil.

They hope that detecting uracil in the blood may help spot early signs the cancer spreading—and blocking UPP1 with drugs could stop the spread before it even starts.

Lead author of the study, Dr Cassie Clarke, said: 'This study represents a major shift in how we think about preventing the spread of cancer.

'By targeting these metabolic changes as early as possible we could stop the cancer progressing and save lives.'

Meanwhile, Dr Catherine Elliot, director of research at Cancer Research UK, said: 'Metastasis—when cancer spreads—is a major factor in breast cancer becoming harder to treat, especially if the cancer returns months or even many years later.

'This discovery gives us new hope for detecting and stopping metastasis early

The research may also help stop the spread of other cancers to other parts of the body, too added Simon Vincent, chief scientific officer at Breast Cancer Now.

'Now we need more research to see if this new insight can be turned into new drugs that stop secondary breast cancer, and potentially other secondary cancers,' he said.

The team of researchers at from the Cancer Research UK Institute and University of Glasgow are now testing the ability of drugs to prevent cancer occurring.


It comes amid an alarming prediction earlier this year that breast cancer deaths in the UK will soar by more than 40 per cent by 2050.

By the same year, globally, another study estimated there will be 3.2million new cases and 1.1million breast-related deaths per year if current trends continue.

The disease is far more prevalent in those over 50, which is the age women typically experience the menopause.

It is the most common type of cancer in the UK, taking the lives of around 11,500 Britons and 42,000 Americans each year.


Scientists discover key way to prevent deadly disease

I lost two family members to breast cancer this year. One in March and one in June. We were all cousins. The one who passed in March fought the disease for 14 years, the other for 4. Both had metastases to other organs. I hope this new finding spares others from this horrible disease.

 

[Disgustedman]

I remember my mother had nine lumps in her breasts at different times fortunately all of them were benign. However she did one day have surgery for a cancer and the doctor removed it and she was never developed cancer after that.

I would support any findings that helped women avoid this terrible problem and disease.

 

[Jackie23]

This is indeed good news, my mother had breast cancer when she was in her early nineties, she went through the treatment process and lived several years after.

 

[hearlady]

This is good news!