Yes the Cologuard is a mail order test, that you do at home, then mail it to a lab for analysis. A Colonoscopy is a medical procedure, done by a Medical Doctor in a medical clinic or a hospital, using a long flexible scope that has a tiny camera and other devices on the end of the cable.
Before you have the scope done, you have to drink a type of "Gastric detergent " for 2 days pre test, to flush all of the fecal matter out of your digestive system, so the Doc can see all of the colon clearly. You will be given a light sedative, so you will be awake but nicely mellow, during the scope procedure. One is a home test, the other is a in hospital medical procedure. JImB.