It used to be that whenever I noticed anything new or different about my health, like a spot that shouldn't be there, or a new ache or sensitivity in my body, I didn't give it much thought - I just applied some OTC medication, or took Ibuprofen and in a few days it would be okay.
Since getting older, I'm more prone to think it may be a sign of something major developing and I should get a dermatology or PCP appointment. I usually wait a reasonable time before doing that, but it hangs like a cloud over my head until it's resolved.