I've been opposed to semiglutide as a weight loss drug having seen one too many (one is enough!) cases of gastroparesis as a dietitian.
But I've now decided to try it, not for weight loss, but micro-dosing for inflammation associated with autoimmune disorders. Semiglutides are showing success in off-label use and in early studies for reducing autoimmune inflammation. Biologics (such as Humira) side effects (increased risk of infection) have scared me so I haven't tried them due to that and also that many patients and rheumatologists report biologics eventually lose efficacy. The adverse GI effects of semiglutides so far seem negligible with microdosing so I'm about to give it a try. Got a two months supply today.