Yes, in my youth I hitched when I was somewhere without a car, or I had a car but it came to rest on a highway shoulder with some technical issue. Hitched in both Canada and the U.S.
One time, I was around 19 and visiting some relatives down in northern California. I was staying about an hour north of San Fransico Bay, and this guy my age & I decided to hitch to Berkeley to go to this fantastic record store that stocked obscure LPs. We got out on Highway 101, stuck out our thumbs and got a ride part way with this smiley middle-aged guy in a pressed shirt & tie, who steered with one hand and shaved his face with an electric razor that plugged into the cigarette lighter. He told us he worked for Falstaff (beer brewer), "a great bunch o' guys!" He got us quite a ways.
Next, we got a ride in a pickup truck with an African-American man, a very talkative, friendly guy. We said we were headed to Berkeley. In the truck bed, there was a load of produce that he'd grown. Turned out, he was a businessman and wanted to get to Berkeley himself. We turned off the highway, somewhere around El Cerrito (?), into a service station that the man owned. He dropped off the produce for his employees there, and they were real pleased to get it. He continued on to Berkeley, and dropped us off near the university campus where the record store was located. We bought some LPs, and had enough money with us to take a bus back to where my buddy lived.
Years later, in my late 20s I was hitching with my girlfriend from the southeast of BC west to Vancouver. I think that was because my car wasn't in traveling shape at the time. We got a ride with a guy in his 30s (pickup truck, a couple of big chainsaws in the back), and after a while he started talking about things like planting some bombs in the venerable Hotel Vancouver (in the financial district)! He was a full-of-.... guy. We didn't believe his plan, but we were glad to get out and rely again on our thumbs! The next ride was with a quiet woman, about 30, who eventually told us she was a professional belly dancer. She took us to her modest older apartment and fed us soup & bread.
I don't remember too many details of the return trip, other than we got a ride for quite a stretch from a young Canada Post driver in an official mail truck. I'm sure giving hitchers a ride could have cost him his job.