I think most of the changes have been for the better. It's hard to think of anything that really was better back "in the day." If we feel that anything was, it's mainly rose-colored nostalgia.
For instance:
Cancer was usually a death sentence.
Women's career options were very limited.
A woman who remained single was mostly pitied.
My dentist never used novocain for ordinary things like fillings.
Free choice in religion, for instance, was much more limited.
People worried a lot more about "sinning," and carried huge burdens of guilt.
Animals were cruelly trapped and killed for their pelts. Fur coats were a big status symbol.
There was no civil rights movement for anyone.
Little or no concern was given to the environment.
Kids who were "different," such as autistic, were shunned and punished.
Women's required clothing was excruciatingly uncomfortable.
There was no air conditioning, so summer could be unbearable.
People died or were crippled by polio.
And that's only the start of my list!