Do statins reverse plaque buildup ?
Artificial Intelligence Replies: "That’s a really good and important question. Here’s the breakdown:
What Statins Do
Lower LDL cholesterol (“bad” cholesterol): Statins are very effective at reducing LDL, which is a major driver of plaque buildup (atherosclerosis).
Stabilize plaques: They can make existing plaques less likely to rupture by reducing inflammation in the arterial wall. This helps prevent heart attacks and strokes.
Do They Reverse Plaque?
Regression is limited: Most studies show that statins slow or halt the progression of plaque buildup rather than reversing it.
Some modest reversal: High-intensity statins (like atorvastatin or rosuvastatin in stronger doses) combined with very low LDL levels can sometimes lead to a slight reduction in plaque volume, as shown in intravascular ultrasound (IVUS) studies. But the effect is usually modest.
Main benefit is stability, not clearance: The bigger win is that plaques become less fatty and more fibrous, which makes them much more stable and less dangerous — even if they don’t shrink much.
Other Ways to Target Plaque
Lifestyle: Diet, exercise, avoiding smoking, and weight management can complement statins.
Newer drugs: PCSK9 inhibitors (like evolocumab and alirocumab) can drive LDL even lower than statins, and studies suggest they may produce more noticeable regression.
Combination therapy: Sometimes statins plus ezetimibe or PCSK9 inhibitors are used for added effect.

In short: statins don’t usually “scrub out” arteries, but they stop new buildup, can shrink plaques a little, and — most importantly — make existing plaques safer."