I have heard about Psilocybin mushrooms: the gal who wrote a newsletter I used to subscribe to had terminal cancer, lived in Oregon where using the mushrooms was legal with a doctor's ok, and did use them once. She said it really helped; the feeling was slightly euphoric and kind of a "one-with-the-universe" feeling; really reduced her anxiety about dying. It was done at a clinic with a doctor present, though; so that's the only way I'd do it. (I'd really love to find something to even just knock an edge off my anxiety.)